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The Journal of Neuroscience, November 5, 2008, 28(45):11635-11641; doi:10.1523/JNEUROSCI.1361-08.2008

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Development/Plasticity/Repair
Glial Chain Migration Requires Pioneer Cells

Benoît Aigouy, Léa Lepelletier, and Angela Giangrande

Institut de Génétique et Biologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique, Université Louis Pasteur, Institut National de la Santé et de la Recherche Médicale, 67404 Illkirch, Communauté Urbaine de Strasbourg, France

Correspondence should be addressed to Angela Giangrande, Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/Université Louis Pasteur, B.P.10142, 67404 Illkirch Cedex, Communauté Urbaine de Strasbourg, France. Email: angela{at}titus.u-strasbg.fr

The migration of glial chains along the nerve entails directional and coordinated movement. Despite its importance in the formation of the nervous system, this process remains poorly understood, because of the difficulty of manipulating identified cells. Using confocal time-lapse and cell ablation in the whole animal, we provide direct evidence for a discrete number of Drosophila peripheral glial cells acting as pioneers and guiding the rest of the migratory chain. These cells are in direct contact with several follower cells through a very long and stable cytoplasmic extension. The presence of pioneer cells and homotypic interactions at the tip of the chain allows coordinated movement and the formation of a continuous sheath around the nerve. These in vivo data open novel perspectives for understanding the cellular bases of vertebrate glial migration in physiological and pathological conditions.

Key words: glia; Drosophila; migration; pioneers; chain; time-lapse

Received Feb. 13, 2008; revised July 20, 2008; accepted Sept. 20, 2008.

Correspondence should be addressed to Angela Giangrande, Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/Université Louis Pasteur, B.P.10142, 67404 Illkirch Cedex, Communauté Urbaine de Strasbourg, France. Email: angela{at}titus.u-strasbg.fr


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